Ultrafast and absolute quantification of SARS-CoV-2 on food using hydrogel RT-LAMP without pre-lysisArticle Published on 2023-01-152022-11-16 Journal: Journal of hazardous materials [Category] SARS, 치료기술, [키워드] Absolute quantification acute respiratory syndrome amplification cold chain Cold chain food contact infection coronavirus faster Food industry hydrogel Hydrogel RT-LAMP isothermal amplification microbe offer POCT point-of-care quantification reproducibility reverse transcription RNA RNA extraction RT-LAMP SARS-CoV-2 sensitivity specificity stability Surveillance Ultrafast detection. virus [DOI] 10.1016/j.jhazmat.2022.130050 PMC 바로가기
Hybridization Approach Toward Novel Antituberculars: Design, Synthesis, and Biological Evaluation of Compounds Combining Pyrazinamide and 4-Aminosalicylic AcidArticle Published on 2023-01-132023-07-11 Journal: ACS Infectious Diseases [Category] COVID19(2023년), [키워드] 4-aminosalicylic acid hybridization Multidrug resistance pyrazinamide stability tuberculosis. [DOI] 10.1021/acsinfecdis.2c00433 PMC 바로가기
Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione zinc. [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysisArticle Published on 2022-12-012022-11-15 Journal: Drug Delivery [Category] COVID19(2023년), SARS, 치료제, [키워드] addition administration Analysis Antiviral antiviral activity Calu-3 Cell characterized Concentration COVID-19 cytotoxicity Favipiravir in vitro indicated Influenza virus Inhaled inhaled formulation inhibitor investigated lung lung epithelial cell lung tissue Lungs media Patient patients with COVID-19 PBS phosphate buffer profile pulmonary RdRP real time required respiratory. RNA-dependent RNA polymerase SARS-CoV-2 stability target Toxicity treat Treatment VERO-E6 viability were infected [DOI] 10.1080/10717544.2022.2118398 PMC 바로가기
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvantsArticle Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 진단, [키워드] abrogated ACE2 addition adjuvant adjuvants Adsorption alum aluminum analysis Antigen approach binding booster Combination Complete conformational Coverage COVID-19 COVID-19 vaccine CpG decrease demonstrated destabilized domain dose ELISA exacerbated facilitate Formulation highlight host cell receptor immune responses immunogenicity IMPROVE in vitro in vivo Interaction interactions mice neutralize neutralizing antibody profile Protein RBD RBD antigen SARS-CoV-2 SARS-CoV-2 pseudovirus spike stability stability profile subunit vaccines temperature the receptor-binding domain Vaccine vaccine. while [DOI] 10.1080/21645515.2022.2079346 PMC 바로가기
The heterogeneous mixing model of COVID-19 with interventionsArticle Published on 2022-11-212022-11-16 Journal: Journal of theoretical biology [Category] 변종, [키워드] Admission age analyzed Breakthrough infection caused China conducted Control Control reproduction number Coverage COVID-19 COVID-19 transmission death effective Effectiveness Epidemic evaluate Future group heterogeneity heterogeneous Heterogeneous mixing Infection Intervention manuscript measure mechanism mutant strain Mutant strains Prevent Prevent infection preventing infection reduce Reproduction number stability submitted Transmission vaccination vaccination strategies. Vaccination strategy Vaccine Vaccines [DOI] 10.1016/j.jtbi.2022.111258 PMC 바로가기
Fully Automated CRISPR-LAMP Platform for SARS-CoV-2 Delta and Omicron VariantsArticle Published on 2022-11-082022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy amplification automated B.1.617.2 Combined CRISPR D614G Delta detect Detection limit diagnostic diagnostic systems IMPROVE limit mutant mutations omicron P681H P681R platform Point mutation RdRP reaction RNA SARS-CoV-2 SARS-CoV-2 strain sensitivity Sensitivity and specificity specificity spike stability T478K variants wild type [DOI] 10.1021/acs.analchem.2c03607 PMC 바로가기
Demographic, behavioural and occupational risk factors associated with SARS-CoV-2 infection in UK healthcare workers: a retrospective observational studyArticle Published on 2022-11-072022-11-15 Journal: BMJ Open [Category] SARS, 변종, 진단, [키워드] 95% CI Analysis assessment behavioural COVID-19 demographic Diseases effective enhanced enrolled Epidemiology Factor General population HCW HCWs Health healthcare Healthcare system healthcare worker higher risk highest hospital identify include Infection infection control investigated Logistic regression measure multivariate logistic regression Observational cohort study occupational Pandemics Personal protective equipment Physiotherapist positive PPE Public public health. questionnaire Regression model Reporting Resilience retrospective risk risk factor risk reduction SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 variant Selection Shrinkage social distancing social distancing measures stability sustained Vaccine variable was used Workplace [DOI] 10.1136/bmjopen-2022-063159 PMC 바로가기
Evaluation of the impact of pre-analytical conditions on sample stability for the detection of SARS-CoV-2 RNAArticle Published on 2022-11-012022-11-15 Journal: Journal of virological methods [Category] SARS, 치료기술, 치료제, [키워드] collected Community condition conditions cycle threshold Demand Diagnosis diagnostics False negative increase in independent Laboratory MOST PBS postal service provide RNA RNA extraction RT-qPCR Sample Sample stability. SARS-CoV-2 SARS-CoV-2 E gene SARS-CoV-2 RNA sensitivity stability Swab temperature tested Transport media transported Variation Viral load VTM [DOI] 10.1016/j.jviromet.2022.114607 PMC 바로가기
From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force fieldArticle Published on 2022-11-012022-11-16 Journal: Journal of computer-aided molecular design [Category] 유전자 메커니즘, [키워드] Abraham Affect alteration Amino acid Antibody neutralization antiviral drugs biological activity calculate complexes Donald evaluated example glycoprotein Intramolecular stability LogPo/w mechanism of action modulation mutated Mutation mutations oncoprotein pharmacological polymorphism Protein Proteins Scoring Scoring function. single nucleotide spike stability susceptibility viral replication [DOI] 10.1007/s10822-022-00477-y PMC 바로가기